Scientists say they have settled one of medicine’s biggest debates after a huge study found that anti-depressants work.

The study, which analysed data from 522 trials involving 116,477 people, found 21 common anti-depressants were all more effective at reducing symptoms of acute depression than dummy pills.

But it also showed big differences in how effective each drug is.

The authors of the report, published in the Lancet, said it showed many more people could benefit from the drugs.

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