First ‘three person baby’ born using new method

Source: BBC

The world’s first baby has been born using a new “three person” fertility technique, New Scientist reveals.

The five-month-old boy has the usual DNA from his mum and dad, plus a tiny bit of genetic code from a donor.

US doctors took the unprecedented step to ensure the baby boy would be free of a genetic condition that his Jordanian mother carries in her genes.

Experts say the move heralds a new era in medicine and could help other families with rare genetic conditions.

But they warn that rigorous checks of this new and controversial technology, called mitochondrial donation, are needed.

It’s not the first time scientists have created babies that have DNA from three people – that breakthrough began in the late 1990s – but it is an entirely new and significant method.

Three person babies

Mitochondria are tiny structures inside nearly every cell of the body that convert food into usable energy.

Some women carry genetic defects in mitochondria and they can pass these on to their children.

In the case of the Jordanian family, it was a disorder called Leigh Syndrome that would have proved fatal to any baby conceived. The family had already experienced the heartache of four miscarriages as well as the death of two children – one at eight months and the other at six years of age.

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Leigh syndrome

  • A severe neurological disorder, affecting at least one in 40,000 new-born babies.
  • Usually becomes apparent during the first year of a child’s life.
  • First signs include vomiting, diarrhoea and difficulty with swallowing.
  • Causes the progressive loss of movement, and deterioration of mental functions.
  • Symptoms are linked to the development of patches of damaged tissue which develop in the brain.
  • Children with the condition usually die within two to three years, usually because of respiratory failure.
  • Mutations in 75 different genes have been linked to the condition.
  • Most of those mutations occur in DNA from the nucleus, but in about one in five cases the culprit is found in mitochondrial DNA.

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2 replies

  1. According my high school biology class a donor enucleated egg cell retains it’s mother’s mitochondria, it’s a surprise it’s taken this long to innovate.

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