Radovan Karadzic is closing his defence saying he takes “moral responsibility” for crimes committed by Bosnian Serbs but denying he ordered killings.
The wartime Bosnian Serb leader set out his case in a written brief before telling the UN tribunal there was not a shred of evidence against him.
He is accused in The Hague of genocide and other crimes, with one charge relating to the Srebrenica massacre.
Prosecutors have called for him to be given a life sentence if convicted.
The 69-year-old political leader of the Bosnian Serbs in the 1990s was handed over to the tribunal when he was arrested in 2008 after 13 years on the run.