Medicine

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Systemic and Orofacial Manifestations of Sarcoidosis: A Comprehensive Review of Pathophysiology, Salivary and Lingual Involvement, and Evolving Therapeutics

Presented by Gemini for Zia H Shah MD Audio teaser: How sarcoidosis mimics failing dental implants Introduction and Epidemiological Framework Sarcoidosis is a multisystem, sterile, non-necrotizing granulomatous disorder of uncertain etiology that represents one of the most complex clinical enigmas in modern immunology and internal medicine. Initially described in 1877, […]

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Eosinophilic Granulomatosis with Polyangiitis: A Comprehensive Review of Pathogenesis, Clinical Manifestations, and Evolving Therapeutic Paradigms

Written by Gemini Audio teaser: When asthma treatments unmask deadly EGPA Introduction to the Disease Spectrum Eosinophilic granulomatosis with polyangiitis (EGPA), historically designated by the eponym Churg-Strauss syndrome, is a rare, complex, and potentially life-threatening systemic necrotizing vasculitis. Clinically characterized by a quintessential triad of adult-onset severe asthma, profound peripheral […]

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Nivolumab in the Treatment of Cancer

Nivolumab (Opdivo) is a fully human IgG4 monoclonal antibody that targets the programmed cell death-1 (PD-1) immune checkpoint receptor on T lymphocytessynapse.patsnap.comsynapse.patsnap.com. By blocking PD-1, nivolumab “releases the brakes” on the immune system, enabling T cells to mount a stronger anti-tumor responsesynapse.patsnap.com. Since its initial approval in 2014, nivolumab has […]