At least 120 people have been killed and 368 injured in an earthquake that hit a mountainous area of central Italy, PM Matteo Renzi has said.
The magnitude-6.2 quake struck at 03:36 (01:36 GMT), 100km (65 miles) north-east of Rome, not far from Perugia.
Many of the dead were in the historic town of Amatrice, where the mayor said three-quarters of the town was destroyed, and in nearby Accumoli.
Many people are still believed to be buried under rubble.
“This is not a final toll,” Mr Renzi warned as he gave the latest figures.
He had earlier paid tribute to the volunteers and civil defence officials who had rushed to the scene in the middle of the night and used their bare hands to dig for survivors.
He promised “no family, no city, no hamlet will be left behind”.
The tremor was felt across Italy, from Bologna in the north to Naples in the south. There have been dozens of aftershocks.
Hardest hit were the small towns and villages in the mountainous area where the regions of Umbria, Lazio and Le Marche meet.
Italy’s civil protection department said that at least 73 people were now known to have been killed.
- In Amatrice at least 35 people have been killed, according to Italian news agency Ansa. Rescuers are trying to free a child trapped under the rubble there, and the missing include three nuns
- In Accumoli, 11 people are known to have been killed, including a mother, father and their two young sons. Mayor Stefano Petrucci told Ansa that not a house in the town was fit for habitation, and they would have to set up tents to house everyone